Effect of Stimulation of α2-Adrenergic Receptors on Action Potential of Working Cardiomyocytes in Rat Atrium


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The study examined the effect of clonidine hydrochloride (10—9-10—5 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α2-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of 10—5 М.

作者简介

T. Zefirov

Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University

编辑信件的主要联系方式.
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan

L. Faskhutdinov

Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University

Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan

N. Ziyatdinova

Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University

Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan

A. Galieva

Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University

Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan

A. Zefirov

Department of Normal Physiology, Kazan State Medical University

Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan, Republic of Tatarstan


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