Email this article Effect of Stimulation of α2-Adrenergic Receptors on Action Potential of Working Cardiomyocytes in Rat Atrium
- Authors: Zefirov T.L.1, Faskhutdinov L.I.1, Ziyatdinova N.I.1, Galieva A.M.1, Zefirov A.L.2
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Affiliations:
- Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
- Department of Normal Physiology, Kazan State Medical University
- Issue: Vol 167, No 5 (2019)
- Pages: 603-605
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241954
- DOI: https://doi.org/10.1007/s10517-019-04579-w
- ID: 241954
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Abstract
The study examined the effect of clonidine hydrochloride (10—9-10—5 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α2-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of 10—5 М.
About the authors
T. L. Zefirov
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Author for correspondence.
Email: zefirovtl@mail.ru
Russian Federation, Kazan
L. I. Faskhutdinov
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
N. I. Ziyatdinova
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
A. M. Galieva
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
A. L. Zefirov
Department of Normal Physiology, Kazan State Medical University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, Republic of Tatarstan
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