Development of Pyrosequencing Assay for Evaluation of Genetic Stability of Vaccine Strains of Live Attenuated Influenza Type B Vaccine
- 作者: Stepanova E.1, Krutikova E.1, Kiseleva I.1, Vasil’eva V.1, Rudenko L.1
-
隶属关系:
- A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine
- 期: 卷 165, 编号 2 (2018)
- 页面: 243-247
- 栏目: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/240198
- DOI: https://doi.org/10.1007/s10517-018-4139-1
- ID: 240198
如何引用文章
详细
We developed a pyrosequencing protocol for monitoring of stability of attenuating mutations in the genome of vaccine reassortants based on master donor virus of Russian live attenuated influenza vaccine B/USSR/60/69. The developed protocol allows rapid and accurate assessment of mutations and can be used for analysis of genetic stability of reassortants during vaccine strain development and manufacturing, as well as genetic stability of vaccine isolates of influenza B virus during pre-clinical and clinical trials.
作者简介
E. Stepanova
A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine
编辑信件的主要联系方式.
Email: fedorova.iem@gmail.com
俄罗斯联邦, St. Petersburg
E. Krutikova
Email: fedorova.iem@gmail.com
I. Kiseleva
Email: fedorova.iem@gmail.com
V. Vasil’eva
Email: fedorova.iem@gmail.com
L. Rudenko
Email: fedorova.iem@gmail.com