Development of Pyrosequencing Assay for Evaluation of Genetic Stability of Vaccine Strains of Live Attenuated Influenza Type B Vaccine
- Авторы: Stepanova E.1, Krutikova E.1, Kiseleva I.1, Vasil’eva V.1, Rudenko L.1
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Учреждения:
- A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine
- Выпуск: Том 165, № 2 (2018)
- Страницы: 243-247
- Раздел: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/240198
- DOI: https://doi.org/10.1007/s10517-018-4139-1
- ID: 240198
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Аннотация
We developed a pyrosequencing protocol for monitoring of stability of attenuating mutations in the genome of vaccine reassortants based on master donor virus of Russian live attenuated influenza vaccine B/USSR/60/69. The developed protocol allows rapid and accurate assessment of mutations and can be used for analysis of genetic stability of reassortants during vaccine strain development and manufacturing, as well as genetic stability of vaccine isolates of influenza B virus during pre-clinical and clinical trials.
Об авторах
E. Stepanova
A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine
Автор, ответственный за переписку.
Email: fedorova.iem@gmail.com
Россия, St. Petersburg
E. Krutikova
Email: fedorova.iem@gmail.com
I. Kiseleva
Email: fedorova.iem@gmail.com
V. Vasil’eva
Email: fedorova.iem@gmail.com
L. Rudenko
Email: fedorova.iem@gmail.com