Development of Pyrosequencing Assay for Evaluation of Genetic Stability of Vaccine Strains of Live Attenuated Influenza Type B Vaccine
- Autores: Stepanova E.1, Krutikova E.1, Kiseleva I.1, Vasil’eva V.1, Rudenko L.1
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Afiliações:
- A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine
- Edição: Volume 165, Nº 2 (2018)
- Páginas: 243-247
- Seção: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/240198
- DOI: https://doi.org/10.1007/s10517-018-4139-1
- ID: 240198
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Resumo
We developed a pyrosequencing protocol for monitoring of stability of attenuating mutations in the genome of vaccine reassortants based on master donor virus of Russian live attenuated influenza vaccine B/USSR/60/69. The developed protocol allows rapid and accurate assessment of mutations and can be used for analysis of genetic stability of reassortants during vaccine strain development and manufacturing, as well as genetic stability of vaccine isolates of influenza B virus during pre-clinical and clinical trials.
Sobre autores
E. Stepanova
A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine
Autor responsável pela correspondência
Email: fedorova.iem@gmail.com
Rússia, St. Petersburg
E. Krutikova
Email: fedorova.iem@gmail.com
I. Kiseleva
Email: fedorova.iem@gmail.com
V. Vasil’eva
Email: fedorova.iem@gmail.com
L. Rudenko
Email: fedorova.iem@gmail.com