Development of Pyrosequencing Assay for Evaluation of Genetic Stability of Vaccine Strains of Live Attenuated Influenza Type B Vaccine
- Авторлар: Stepanova E.1, Krutikova E.1, Kiseleva I.1, Vasil’eva V.1, Rudenko L.1
-
Мекемелер:
- A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine
- Шығарылым: Том 165, № 2 (2018)
- Беттер: 243-247
- Бөлім: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/240198
- DOI: https://doi.org/10.1007/s10517-018-4139-1
- ID: 240198
Дәйексөз келтіру
Аннотация
We developed a pyrosequencing protocol for monitoring of stability of attenuating mutations in the genome of vaccine reassortants based on master donor virus of Russian live attenuated influenza vaccine B/USSR/60/69. The developed protocol allows rapid and accurate assessment of mutations and can be used for analysis of genetic stability of reassortants during vaccine strain development and manufacturing, as well as genetic stability of vaccine isolates of influenza B virus during pre-clinical and clinical trials.
Авторлар туралы
E. Stepanova
A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine
Хат алмасуға жауапты Автор.
Email: fedorova.iem@gmail.com
Ресей, St. Petersburg
E. Krutikova
Email: fedorova.iem@gmail.com
I. Kiseleva
Email: fedorova.iem@gmail.com
V. Vasil’eva
Email: fedorova.iem@gmail.com
L. Rudenko
Email: fedorova.iem@gmail.com