Preventive Effects of Oxidized Dextran on Functional Activity of Pulmonary Macrophages in Mice Infected with Influenza A Virus
- 作者: Potapova O.1, Cherdantseva L.2, Kovner A.2, Sharkova T.1, Troitskii A.2, Shestopalov A.2, Shkurupy V.1
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隶属关系:
- Optimum Medical Laboratory, Research-and-Educational Center
- Research Institute of Experimental and Clinical Medicine
- 期: 卷 165, 编号 1 (2018)
- 页面: 57-60
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239972
- DOI: https://doi.org/10.1007/s10517-018-4098-6
- ID: 239972
如何引用文章
详细
We analyzed cytokine profile of pulmonary macrophages in mice infected with highly pathogenic influenza A/H5N1 virus after preventive injections of oxidized dextran. Light microscopy, immunohistochemistry, and morphometric examinations showed that preventive injections of oxidized dextran led to more effective virus elimination, modulation of the proinflammatory cytokine response, and host antiviral response and reduce animal mortality. Our findings allow recommending oxidized dextran for further studies in order to create a vaccine with antiviral and adjuvant potencies.
作者简介
O. Potapova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
俄罗斯联邦, Sochi
L. Cherdantseva
Research Institute of Experimental and Clinical Medicine
编辑信件的主要联系方式.
Email: cherdanceff@yandex.ru
俄罗斯联邦, Novosibirsk
A. Kovner
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
俄罗斯联邦, Novosibirsk
T. Sharkova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
俄罗斯联邦, Sochi
A. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
俄罗斯联邦, Novosibirsk
A. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
俄罗斯联邦, Novosibirsk
V. Shkurupy
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
俄罗斯联邦, Sochi