Preventive Effects of Oxidized Dextran on Functional Activity of Pulmonary Macrophages in Mice Infected with Influenza A Virus
- Авторы: Potapova O.1, Cherdantseva L.2, Kovner A.2, Sharkova T.1, Troitskii A.2, Shestopalov A.2, Shkurupy V.1
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Учреждения:
- Optimum Medical Laboratory, Research-and-Educational Center
- Research Institute of Experimental and Clinical Medicine
- Выпуск: Том 165, № 1 (2018)
- Страницы: 57-60
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239972
- DOI: https://doi.org/10.1007/s10517-018-4098-6
- ID: 239972
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Аннотация
We analyzed cytokine profile of pulmonary macrophages in mice infected with highly pathogenic influenza A/H5N1 virus after preventive injections of oxidized dextran. Light microscopy, immunohistochemistry, and morphometric examinations showed that preventive injections of oxidized dextran led to more effective virus elimination, modulation of the proinflammatory cytokine response, and host antiviral response and reduce animal mortality. Our findings allow recommending oxidized dextran for further studies in order to create a vaccine with antiviral and adjuvant potencies.
Об авторах
O. Potapova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Россия, Sochi
L. Cherdantseva
Research Institute of Experimental and Clinical Medicine
Автор, ответственный за переписку.
Email: cherdanceff@yandex.ru
Россия, Novosibirsk
A. Kovner
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Россия, Novosibirsk
T. Sharkova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Россия, Sochi
A. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Россия, Novosibirsk
A. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Россия, Novosibirsk
V. Shkurupy
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Россия, Sochi