Preventive Effects of Oxidized Dextran on Functional Activity of Pulmonary Macrophages in Mice Infected with Influenza A Virus
- Авторлар: Potapova O.1, Cherdantseva L.2, Kovner A.2, Sharkova T.1, Troitskii A.2, Shestopalov A.2, Shkurupy V.1
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Мекемелер:
- Optimum Medical Laboratory, Research-and-Educational Center
- Research Institute of Experimental and Clinical Medicine
- Шығарылым: Том 165, № 1 (2018)
- Беттер: 57-60
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239972
- DOI: https://doi.org/10.1007/s10517-018-4098-6
- ID: 239972
Дәйексөз келтіру
Аннотация
We analyzed cytokine profile of pulmonary macrophages in mice infected with highly pathogenic influenza A/H5N1 virus after preventive injections of oxidized dextran. Light microscopy, immunohistochemistry, and morphometric examinations showed that preventive injections of oxidized dextran led to more effective virus elimination, modulation of the proinflammatory cytokine response, and host antiviral response and reduce animal mortality. Our findings allow recommending oxidized dextran for further studies in order to create a vaccine with antiviral and adjuvant potencies.
Авторлар туралы
O. Potapova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Ресей, Sochi
L. Cherdantseva
Research Institute of Experimental and Clinical Medicine
Хат алмасуға жауапты Автор.
Email: cherdanceff@yandex.ru
Ресей, Novosibirsk
A. Kovner
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Ресей, Novosibirsk
T. Sharkova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Ресей, Sochi
A. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Ресей, Novosibirsk
A. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Ресей, Novosibirsk
V. Shkurupy
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Ресей, Sochi