Preventive Effects of Oxidized Dextran on Functional Activity of Pulmonary Macrophages in Mice Infected with Influenza A Virus
- Autores: Potapova O.1, Cherdantseva L.2, Kovner A.2, Sharkova T.1, Troitskii A.2, Shestopalov A.2, Shkurupy V.1
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Afiliações:
- Optimum Medical Laboratory, Research-and-Educational Center
- Research Institute of Experimental and Clinical Medicine
- Edição: Volume 165, Nº 1 (2018)
- Páginas: 57-60
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239972
- DOI: https://doi.org/10.1007/s10517-018-4098-6
- ID: 239972
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Resumo
We analyzed cytokine profile of pulmonary macrophages in mice infected with highly pathogenic influenza A/H5N1 virus after preventive injections of oxidized dextran. Light microscopy, immunohistochemistry, and morphometric examinations showed that preventive injections of oxidized dextran led to more effective virus elimination, modulation of the proinflammatory cytokine response, and host antiviral response and reduce animal mortality. Our findings allow recommending oxidized dextran for further studies in order to create a vaccine with antiviral and adjuvant potencies.
Sobre autores
O. Potapova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Rússia, Sochi
L. Cherdantseva
Research Institute of Experimental and Clinical Medicine
Autor responsável pela correspondência
Email: cherdanceff@yandex.ru
Rússia, Novosibirsk
A. Kovner
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Rússia, Novosibirsk
T. Sharkova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Rússia, Sochi
A. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Rússia, Novosibirsk
A. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Rússia, Novosibirsk
V. Shkurupy
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Rússia, Sochi