Preventive Effects of Oxidized Dextran on Functional Activity of Pulmonary Macrophages in Mice Infected with Influenza A Virus
- Authors: Potapova O.V.1, Cherdantseva L.A.2, Kovner A.V.2, Sharkova T.V.1, Troitskii A.V.2, Shestopalov A.M.2, Shkurupy V.A.1
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Affiliations:
- Optimum Medical Laboratory, Research-and-Educational Center
- Research Institute of Experimental and Clinical Medicine
- Issue: Vol 165, No 1 (2018)
- Pages: 57-60
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239972
- DOI: https://doi.org/10.1007/s10517-018-4098-6
- ID: 239972
Cite item
Abstract
We analyzed cytokine profile of pulmonary macrophages in mice infected with highly pathogenic influenza A/H5N1 virus after preventive injections of oxidized dextran. Light microscopy, immunohistochemistry, and morphometric examinations showed that preventive injections of oxidized dextran led to more effective virus elimination, modulation of the proinflammatory cytokine response, and host antiviral response and reduce animal mortality. Our findings allow recommending oxidized dextran for further studies in order to create a vaccine with antiviral and adjuvant potencies.
About the authors
O. V. Potapova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Russian Federation, Sochi
L. A. Cherdantseva
Research Institute of Experimental and Clinical Medicine
Author for correspondence.
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
A. V. Kovner
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
T. V. Sharkova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Russian Federation, Sochi
A. V. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
A. M. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
V. A. Shkurupy
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Russian Federation, Sochi