Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease
- 作者: Bol’shakova A.1, Kraskovskaya N.1, Gainullina A.1, Kukanova E.1, Vlasova O.1, Bezprozvanny I.1,2
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隶属关系:
- Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
- Department of Physiology, UT Southwestern Medical Center at Dallas
- 期: 卷 164, 编号 2 (2017)
- 页面: 252-258
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239539
- DOI: https://doi.org/10.1007/s10517-017-3968-7
- ID: 239539
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详细
Huntington’s disease is a hereditary neurodegenerative disease that primarily affects striatal neurons. Recent studies demonstrated abnormalities in calcium regulation in striatal neurons in Huntington’s disease, which leads to elimination of synaptic connections between cortical and striatal neurons. In the present study, we focused on the neuroprotective properties of σ1-receptor, because one of its main functions is associated with modulation of calcium homeostasis in cells. The application of selective σ1-receptor agonists to the corticostriatal cell culture restores synaptic connections between the cortical and striatal neurons. Based on the obtained data, we assume that σ1-receptor is a promising target for the development of drugs for the therapy of Huntington’s disease.
作者简介
A. Bol’shakova
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
俄罗斯联邦, St. Petersburg
N. Kraskovskaya
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
编辑信件的主要联系方式.
Email: ninakraskovskaya@gmail.com
俄罗斯联邦, St. Petersburg
A. Gainullina
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
俄罗斯联邦, St. Petersburg
E. Kukanova
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
俄罗斯联邦, St. Petersburg
O. Vlasova
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
俄罗斯联邦, St. Petersburg
I. Bezprozvanny
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University; Department of Physiology, UT Southwestern Medical Center at Dallas
编辑信件的主要联系方式.
Email: mnlabspb@gmail.com
俄罗斯联邦, St. Petersburg; Dallas