Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease
- Authors: Bol’shakova A.V.1, Kraskovskaya N.A.1, Gainullina A.N.1, Kukanova E.O.1, Vlasova O.L.1, Bezprozvanny I.B.1,2
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Affiliations:
- Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
- Department of Physiology, UT Southwestern Medical Center at Dallas
- Issue: Vol 164, No 2 (2017)
- Pages: 252-258
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239539
- DOI: https://doi.org/10.1007/s10517-017-3968-7
- ID: 239539
Cite item
Abstract
Huntington’s disease is a hereditary neurodegenerative disease that primarily affects striatal neurons. Recent studies demonstrated abnormalities in calcium regulation in striatal neurons in Huntington’s disease, which leads to elimination of synaptic connections between cortical and striatal neurons. In the present study, we focused on the neuroprotective properties of σ1-receptor, because one of its main functions is associated with modulation of calcium homeostasis in cells. The application of selective σ1-receptor agonists to the corticostriatal cell culture restores synaptic connections between the cortical and striatal neurons. Based on the obtained data, we assume that σ1-receptor is a promising target for the development of drugs for the therapy of Huntington’s disease.
About the authors
A. V. Bol’shakova
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
Russian Federation, St. Petersburg
N. A. Kraskovskaya
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Author for correspondence.
Email: ninakraskovskaya@gmail.com
Russian Federation, St. Petersburg
A. N. Gainullina
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
Russian Federation, St. Petersburg
E. O. Kukanova
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
Russian Federation, St. Petersburg
O. L. Vlasova
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
Russian Federation, St. Petersburg
I. B. Bezprozvanny
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University; Department of Physiology, UT Southwestern Medical Center at Dallas
Author for correspondence.
Email: mnlabspb@gmail.com
Russian Federation, St. Petersburg; Dallas