Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease
- Autores: Bol’shakova A.1, Kraskovskaya N.1, Gainullina A.1, Kukanova E.1, Vlasova O.1, Bezprozvanny I.1,2
-
Afiliações:
- Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
- Department of Physiology, UT Southwestern Medical Center at Dallas
- Edição: Volume 164, Nº 2 (2017)
- Páginas: 252-258
- Seção: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239539
- DOI: https://doi.org/10.1007/s10517-017-3968-7
- ID: 239539
Citar
Resumo
Huntington’s disease is a hereditary neurodegenerative disease that primarily affects striatal neurons. Recent studies demonstrated abnormalities in calcium regulation in striatal neurons in Huntington’s disease, which leads to elimination of synaptic connections between cortical and striatal neurons. In the present study, we focused on the neuroprotective properties of σ1-receptor, because one of its main functions is associated with modulation of calcium homeostasis in cells. The application of selective σ1-receptor agonists to the corticostriatal cell culture restores synaptic connections between the cortical and striatal neurons. Based on the obtained data, we assume that σ1-receptor is a promising target for the development of drugs for the therapy of Huntington’s disease.
Sobre autores
A. Bol’shakova
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
Rússia, St. Petersburg
N. Kraskovskaya
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Autor responsável pela correspondência
Email: ninakraskovskaya@gmail.com
Rússia, St. Petersburg
A. Gainullina
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
Rússia, St. Petersburg
E. Kukanova
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
Rússia, St. Petersburg
O. Vlasova
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University
Email: mnlabspb@gmail.com
Rússia, St. Petersburg
I. Bezprozvanny
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University; Department of Physiology, UT Southwestern Medical Center at Dallas
Autor responsável pela correspondência
Email: mnlabspb@gmail.com
Rússia, St. Petersburg; Dallas