Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo
- 作者: Popova N.1, Sysoeva G.2, Nikolin V.1, Kaledin V.1, Tretyakov E.3, Edeeva M.3, Balakhnin S.4, Lushnikova E.4, Audran G.5, Mark S.3
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隶属关系:
- Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
- Institute of Molecular Pathology and Pathomorphology
- Aix Marseille University
- 期: 卷 164, 编号 1 (2017)
- 页面: 49-53
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239354
- DOI: https://doi.org/10.1007/s10517-017-3924-6
- ID: 239354
如何引用文章
详细
Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.
作者简介
N. Popova
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
G. Sysoeva
Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology
Email: pathol@inbox.ru
俄罗斯联邦, Koltsovo, Novosibirsk Region
V. Nikolin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
V. Kaledin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
E. Tretyakov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
M. Edeeva
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
S. Balakhnin
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
G. Audran
Aix Marseille University
Email: pathol@inbox.ru
法国, Provence
S. Mark
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
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