Email this article Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo
- Authors: Popova N.A.1, Sysoeva G.M.2, Nikolin V.P.1, Kaledin V.I.1, Tretyakov E.V.3, Edeeva M.V.3, Balakhnin S.M.4, Lushnikova E.L.4, Audran G.5, Mark S.3
-
Affiliations:
- Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
- Institute of Molecular Pathology and Pathomorphology
- Aix Marseille University
- Issue: Vol 164, No 1 (2017)
- Pages: 49-53
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239354
- DOI: https://doi.org/10.1007/s10517-017-3924-6
- ID: 239354
Cite item
Open Access
Access granted
Subscription Access
Abstract
Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.
About the authors
N. A. Popova
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
G. M. Sysoeva
Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology
Email: pathol@inbox.ru
Russian Federation, Koltsovo, Novosibirsk Region
V. P. Nikolin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
V. I. Kaledin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
E. V. Tretyakov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
M. V. Edeeva
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
S. M. Balakhnin
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
E. L. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
G. Audran
Aix Marseille University
Email: pathol@inbox.ru
France, Provence
S. Mark
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
