Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo
- Авторы: Popova N.1, Sysoeva G.2, Nikolin V.1, Kaledin V.1, Tretyakov E.3, Edeeva M.3, Balakhnin S.4, Lushnikova E.4, Audran G.5, Mark S.3
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Учреждения:
- Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
- Institute of Molecular Pathology and Pathomorphology
- Aix Marseille University
- Выпуск: Том 164, № 1 (2017)
- Страницы: 49-53
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239354
- DOI: https://doi.org/10.1007/s10517-017-3924-6
- ID: 239354
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Аннотация
Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.
Об авторах
N. Popova
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: pathol@inbox.ru
Россия, Novosibirsk
G. Sysoeva
Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology
Email: pathol@inbox.ru
Россия, Koltsovo, Novosibirsk Region
V. Nikolin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Россия, Novosibirsk
V. Kaledin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Россия, Novosibirsk
E. Tretyakov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Россия, Novosibirsk
M. Edeeva
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Россия, Novosibirsk
S. Balakhnin
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
G. Audran
Aix Marseille University
Email: pathol@inbox.ru
Франция, Provence
S. Mark
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Россия, Novosibirsk