Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo
- Авторлар: Popova N.1, Sysoeva G.2, Nikolin V.1, Kaledin V.1, Tretyakov E.3, Edeeva M.3, Balakhnin S.4, Lushnikova E.4, Audran G.5, Mark S.3
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Мекемелер:
- Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
- Institute of Molecular Pathology and Pathomorphology
- Aix Marseille University
- Шығарылым: Том 164, № 1 (2017)
- Беттер: 49-53
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239354
- DOI: https://doi.org/10.1007/s10517-017-3924-6
- ID: 239354
Дәйексөз келтіру
Аннотация
Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.
Авторлар туралы
N. Popova
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: pathol@inbox.ru
Ресей, Novosibirsk
G. Sysoeva
Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology
Email: pathol@inbox.ru
Ресей, Koltsovo, Novosibirsk Region
V. Nikolin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Ресей, Novosibirsk
V. Kaledin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Ресей, Novosibirsk
E. Tretyakov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Ресей, Novosibirsk
M. Edeeva
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Ресей, Novosibirsk
S. Balakhnin
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
G. Audran
Aix Marseille University
Email: pathol@inbox.ru
Франция, Provence
S. Mark
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Ресей, Novosibirsk