电邮这篇文章 Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning
- 作者: Terekhov S.1, Palikov V.2, Palikova Y.2, Dyachenko I.2, Shamborant O.1, Smirnov I.1, Masson P.3, Gabibov A.1
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隶属关系:
- V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Kazan (Volga Region) Federal University
- 期: 卷 163, 编号 4 (2017)
- 页面: 430-435
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238965
- DOI: https://doi.org/10.1007/s10517-017-3821-z
- ID: 238965
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详细
We present a procedure for optimizing the expression of recombinant tetrameric butyrylcholinesterase that enables large-scale production with the yield >30 mg/liter (>90 mg/roller bottle). Intravenous injection of the preparation significantly increased survival and decreased the severity of symptoms of poisoning with paraoxon, an organophosphorus toxin.
作者简介
S. Terekhov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: sterekhoff@mail.ru
俄罗斯联邦, Moscow
V. Palikov
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
俄罗斯联邦, Pushchino, Moscow Region
Y. Palikova
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
俄罗斯联邦, Pushchino, Moscow Region
I. Dyachenko
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
俄罗斯联邦, Pushchino, Moscow Region
O. Shamborant
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
俄罗斯联邦, Moscow
I. Smirnov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
俄罗斯联邦, Moscow
P. Masson
Kazan (Volga Region) Federal University
Email: sterekhoff@mail.ru
俄罗斯联邦, Republic of Tatarstan, Kazan
A. Gabibov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
俄罗斯联邦, Moscow
