Отправить статью по E-mail Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning
- Авторы: Terekhov S.S.1, Palikov V.A.2, Palikova Y.A.2, Dyachenko I.A.2, Shamborant O.G.1, Smirnov I.V.1, Masson P.3, Gabibov A.G.1
-
Учреждения:
- V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Kazan (Volga Region) Federal University
- Выпуск: Том 163, № 4 (2017)
- Страницы: 430-435
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238965
- DOI: https://doi.org/10.1007/s10517-017-3821-z
- ID: 238965
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
We present a procedure for optimizing the expression of recombinant tetrameric butyrylcholinesterase that enables large-scale production with the yield >30 mg/liter (>90 mg/roller bottle). Intravenous injection of the preparation significantly increased survival and decreased the severity of symptoms of poisoning with paraoxon, an organophosphorus toxin.
Об авторах
S. Terekhov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: sterekhoff@mail.ru
Россия, Moscow
V. Palikov
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Россия, Pushchino, Moscow Region
Y. Palikova
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Россия, Pushchino, Moscow Region
I. Dyachenko
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Россия, Pushchino, Moscow Region
O. Shamborant
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Россия, Moscow
I. Smirnov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Россия, Moscow
P. Masson
Kazan (Volga Region) Federal University
Email: sterekhoff@mail.ru
Россия, Republic of Tatarstan, Kazan
A. Gabibov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Россия, Moscow
Дополнительные файлы
