Enviar artigo por via de e-mail Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning
- Autores: Terekhov S.1, Palikov V.2, Palikova Y.2, Dyachenko I.2, Shamborant O.1, Smirnov I.1, Masson P.3, Gabibov A.1
-
Afiliações:
- V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Kazan (Volga Region) Federal University
- Edição: Volume 163, Nº 4 (2017)
- Páginas: 430-435
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238965
- DOI: https://doi.org/10.1007/s10517-017-3821-z
- ID: 238965
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
We present a procedure for optimizing the expression of recombinant tetrameric butyrylcholinesterase that enables large-scale production with the yield >30 mg/liter (>90 mg/roller bottle). Intravenous injection of the preparation significantly increased survival and decreased the severity of symptoms of poisoning with paraoxon, an organophosphorus toxin.
Sobre autores
S. Terekhov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Autor responsável pela correspondência
Email: sterekhoff@mail.ru
Rússia, Moscow
V. Palikov
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Rússia, Pushchino, Moscow Region
Y. Palikova
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Rússia, Pushchino, Moscow Region
I. Dyachenko
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Rússia, Pushchino, Moscow Region
O. Shamborant
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Rússia, Moscow
I. Smirnov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Rússia, Moscow
P. Masson
Kazan (Volga Region) Federal University
Email: sterekhoff@mail.ru
Rússia, Republic of Tatarstan, Kazan
A. Gabibov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Rússia, Moscow
