Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma
- 作者: Drozd N.1, Shagdarova B.2, Il’ina A.2, Varlamov V.2
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隶属关系:
- National Research Center for Hematology, Ministry of Health of the Russian Federation
- Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
- 期: 卷 163, 编号 3 (2017)
- 页面: 340-343
- 栏目: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/238875
- DOI: https://doi.org/10.1007/s10517-017-3799-6
- ID: 238875
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详细
Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.
作者简介
N. Drozd
National Research Center for Hematology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: nndrozd@mail.ru
俄罗斯联邦, Moscow
B. Shagdarova
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
俄罗斯联邦, Moscow
A. Il’ina
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
俄罗斯联邦, Moscow
V. Varlamov
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
俄罗斯联邦, Moscow