Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma
- Авторлар: Drozd N.1, Shagdarova B.2, Il’ina A.2, Varlamov V.2
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Мекемелер:
- National Research Center for Hematology, Ministry of Health of the Russian Federation
- Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
- Шығарылым: Том 163, № 3 (2017)
- Беттер: 340-343
- Бөлім: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/238875
- DOI: https://doi.org/10.1007/s10517-017-3799-6
- ID: 238875
Дәйексөз келтіру
Аннотация
Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.
Авторлар туралы
N. Drozd
National Research Center for Hematology, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: nndrozd@mail.ru
Ресей, Moscow
B. Shagdarova
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
Ресей, Moscow
A. Il’ina
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
Ресей, Moscow
V. Varlamov
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
Ресей, Moscow