Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma
- Authors: Drozd N.N.1, Shagdarova B.T.2, Il’ina A.V.2, Varlamov V.P.2
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Affiliations:
- National Research Center for Hematology, Ministry of Health of the Russian Federation
- Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
- Issue: Vol 163, No 3 (2017)
- Pages: 340-343
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/238875
- DOI: https://doi.org/10.1007/s10517-017-3799-6
- ID: 238875
Cite item
Abstract
Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.
About the authors
N. N. Drozd
National Research Center for Hematology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: nndrozd@mail.ru
Russian Federation, Moscow
B. Ts. Shagdarova
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
Russian Federation, Moscow
A. V. Il’ina
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
Russian Federation, Moscow
V. P. Varlamov
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
Russian Federation, Moscow