Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma
- Авторы: Drozd N.1, Shagdarova B.2, Il’ina A.2, Varlamov V.2
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Учреждения:
- National Research Center for Hematology, Ministry of Health of the Russian Federation
- Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
- Выпуск: Том 163, № 3 (2017)
- Страницы: 340-343
- Раздел: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/238875
- DOI: https://doi.org/10.1007/s10517-017-3799-6
- ID: 238875
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Аннотация
Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.
Об авторах
N. Drozd
National Research Center for Hematology, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: nndrozd@mail.ru
Россия, Moscow
B. Shagdarova
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
Россия, Moscow
A. Il’ina
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
Россия, Moscow
V. Varlamov
Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: nndrozd@mail.ru
Россия, Moscow
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