电邮这篇文章 Analysis of Gut Microbiota in Patients with Parkinson’s Disease
- 作者: Petrov V.1, Saltykova I.1, Zhukova I.1, Alifirova V.1, Zhukova N.1, Dorofeeva Y.1, Tyakht A.2, Kovarsky B.2, Alekseev D.2, Kostryukova E.2, Mironova Y.1, Izhboldina O.1, Nikitina M.1, Perevozchikova T.1, Fait E.1, Babenko V.2, Vakhitova M.2, Govorun V.2,3, Sazonov A.1,4
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隶属关系:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
- M. V. Lomonosov Moscow State University
- 期: 卷 162, 编号 6 (2017)
- 页面: 734-737
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238509
- DOI: https://doi.org/10.1007/s10517-017-3700-7
- ID: 238509
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详细
Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.
作者简介
V. Petrov
Siberian State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
I. Saltykova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
I. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
V. Alifirova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
N. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
Yu. Dorofeeva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
A. Tyakht
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Moscow
B. Kovarsky
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Moscow
D. Alekseev
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Moscow
E. Kostryukova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Moscow
Yu. Mironova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
O. Izhboldina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
M. Nikitina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
T. Perevozchikova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
E. Fait
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk
V. Babenko
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Moscow
M. Vakhitova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Moscow
V. Govorun
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Moscow; Moscow
A. Sazonov
Siberian State Medical University, Ministry of Health of the Russian Federation; M. V. Lomonosov Moscow State University
Email: vyacheslav.a.petrov@mail.ru
俄罗斯联邦, Tomsk; Moscow
