Analysis of Gut Microbiota in Patients with Parkinson’s Disease
- Authors: Petrov V.A.1, Saltykova I.V.1, Zhukova I.A.1, Alifirova V.M.1, Zhukova N.G.1, Dorofeeva Y.B.1, Tyakht A.V.2, Kovarsky B.A.2, Alekseev D.G.2, Kostryukova E.S.2, Mironova Y.S.1, Izhboldina O.P.1, Nikitina M.A.1, Perevozchikova T.V.1, Fait E.A.1, Babenko V.V.2, Vakhitova M.T.2, Govorun V.M.2,3, Sazonov A.E.1,4
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Affiliations:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
- M. V. Lomonosov Moscow State University
- Issue: Vol 162, No 6 (2017)
- Pages: 734-737
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238509
- DOI: https://doi.org/10.1007/s10517-017-3700-7
- ID: 238509
Cite item
Abstract
Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.
About the authors
V. A. Petrov
Siberian State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
I. V. Saltykova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
I. A. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
V. M. Alifirova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
N. G. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
Yu. B. Dorofeeva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
A. V. Tyakht
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Moscow
B. A. Kovarsky
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Moscow
D. G. Alekseev
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Moscow
E. S. Kostryukova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Moscow
Yu. S. Mironova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
O. P. Izhboldina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
M. A. Nikitina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
T. V. Perevozchikova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
E. A. Fait
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk
V. V. Babenko
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Moscow
M. T. Vakhitova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Moscow
V. M. Govorun
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Moscow; Moscow
A. E. Sazonov
Siberian State Medical University, Ministry of Health of the Russian Federation; M. V. Lomonosov Moscow State University
Email: vyacheslav.a.petrov@mail.ru
Russian Federation, Tomsk; Moscow