Enviar artigo por via de e-mail Analysis of Gut Microbiota in Patients with Parkinson’s Disease
- Autores: Petrov V.1, Saltykova I.1, Zhukova I.1, Alifirova V.1, Zhukova N.1, Dorofeeva Y.1, Tyakht A.2, Kovarsky B.2, Alekseev D.2, Kostryukova E.2, Mironova Y.1, Izhboldina O.1, Nikitina M.1, Perevozchikova T.1, Fait E.1, Babenko V.2, Vakhitova M.2, Govorun V.2,3, Sazonov A.1,4
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Afiliações:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
- M. V. Lomonosov Moscow State University
- Edição: Volume 162, Nº 6 (2017)
- Páginas: 734-737
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238509
- DOI: https://doi.org/10.1007/s10517-017-3700-7
- ID: 238509
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Resumo
Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.
Sobre autores
V. Petrov
Siberian State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
I. Saltykova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
I. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
V. Alifirova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
N. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
Yu. Dorofeeva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
A. Tyakht
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Rússia, Moscow
B. Kovarsky
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Rússia, Moscow
D. Alekseev
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Rússia, Moscow
E. Kostryukova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Rússia, Moscow
Yu. Mironova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
O. Izhboldina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
M. Nikitina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
T. Perevozchikova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
E. Fait
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk
V. Babenko
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Rússia, Moscow
M. Vakhitova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Rússia, Moscow
V. Govorun
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
Email: vyacheslav.a.petrov@mail.ru
Rússia, Moscow; Moscow
A. Sazonov
Siberian State Medical University, Ministry of Health of the Russian Federation; M. V. Lomonosov Moscow State University
Email: vyacheslav.a.petrov@mail.ru
Rússia, Tomsk; Moscow
