Отправить статью по E-mail Analysis of Gut Microbiota in Patients with Parkinson’s Disease
- Авторы: Petrov V.1, Saltykova I.1, Zhukova I.1, Alifirova V.1, Zhukova N.1, Dorofeeva Y.1, Tyakht A.2, Kovarsky B.2, Alekseev D.2, Kostryukova E.2, Mironova Y.1, Izhboldina O.1, Nikitina M.1, Perevozchikova T.1, Fait E.1, Babenko V.2, Vakhitova M.2, Govorun V.2,3, Sazonov A.1,4
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Учреждения:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
- M. V. Lomonosov Moscow State University
- Выпуск: Том 162, № 6 (2017)
- Страницы: 734-737
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238509
- DOI: https://doi.org/10.1007/s10517-017-3700-7
- ID: 238509
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Аннотация
Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.
Об авторах
V. Petrov
Siberian State Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
I. Saltykova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
I. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
V. Alifirova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
N. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
Yu. Dorofeeva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
A. Tyakht
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Россия, Moscow
B. Kovarsky
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Россия, Moscow
D. Alekseev
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Россия, Moscow
E. Kostryukova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Россия, Moscow
Yu. Mironova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
O. Izhboldina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
M. Nikitina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
T. Perevozchikova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
E. Fait
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk
V. Babenko
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Россия, Moscow
M. Vakhitova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Россия, Moscow
V. Govorun
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
Email: vyacheslav.a.petrov@mail.ru
Россия, Moscow; Moscow
A. Sazonov
Siberian State Medical University, Ministry of Health of the Russian Federation; M. V. Lomonosov Moscow State University
Email: vyacheslav.a.petrov@mail.ru
Россия, Tomsk; Moscow
