Biological Activity of Spirocyclic Hydroxamic Acids
- 作者: Neganova M.1, Mishchenko D.1, Serkova T.2, Vystorop I.1, Shevtsova E.2
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隶属关系:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- 期: 卷 162, 编号 2 (2016)
- 页面: 228-230
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238063
- DOI: https://doi.org/10.1007/s10517-016-3582-0
- ID: 238063
如何引用文章
详细
Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.
作者简介
M. Neganova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
D. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
T. Serkova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
I. Vystorop
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
E. Shevtsova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka