Biological Activity of Spirocyclic Hydroxamic Acids

M. E. Neganova; D. V. Mishchenko; T. P. Serkova; I. V. Vystorop; E. F. Shevtsova

doi:10.1007/s10517-016-3582-0

Biological Activity of Spirocyclic Hydroxamic Acids

Authors: Neganova M.E.¹, Mishchenko D.V.¹, Serkova T.P.², Vystorop I.V.¹, Shevtsova E.F.²
Affiliations:
1. Institute of Problems of Chemical Physics, Russian Academy of Sciences
2. Institute of Physiologically Active Compounds, Russian Academy of Sciences
Issue: Vol 162, No 2 (2016)
Pages: 228-230
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238063
DOI: https://doi.org/10.1007/s10517-016-3582-0
ID: 238063

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Abstract

Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.