Biological Activity of Spirocyclic Hydroxamic Acids

M. E. Neganova; D. V. Mishchenko; T. P. Serkova; I. V. Vystorop; E. F. Shevtsova

doi:10.1007/s10517-016-3582-0

Biological Activity of Spirocyclic Hydroxamic Acids

Autores: Neganova M.¹, Mishchenko D.¹, Serkova T.², Vystorop I.¹, Shevtsova E.²
Afiliações:
1. Institute of Problems of Chemical Physics, Russian Academy of Sciences
2. Institute of Physiologically Active Compounds, Russian Academy of Sciences
Edição: Volume 162, Nº 2 (2016)
Páginas: 228-230
Seção: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238063
DOI: https://doi.org/10.1007/s10517-016-3582-0
ID: 238063

Citar

Texto integral

Acesso aberto
Acesso é fechado

Acesso está concedido
Acesso é fechado

Somente assinantes

Resumo
Sobre autores
Bibliografia
Estatísticas

Resumo

Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.