Enviar artigo por via de e-mail Biological Activity of Spirocyclic Hydroxamic Acids
- Autores: Neganova M.E.1, Mishchenko D.V.1, Serkova T.P.2, Vystorop I.V.1, Shevtsova E.F.2
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Afiliações:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Edição: Volume 162, Nº 2 (2016)
- Páginas: 228-230
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238063
- DOI: https://doi.org/10.1007/s10517-016-3582-0
- ID: 238063
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Resumo
Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.
Sobre autores
M. Neganova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Autor responsável pela correspondência
Email: neganova83@mail.ru
Rússia, Chernogolovka
D. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka
T. Serkova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka
I. Vystorop
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka
E. Shevtsova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka
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