Biological Activity of Spirocyclic Hydroxamic Acids
- Authors: Neganova M.E.1, Mishchenko D.V.1, Serkova T.P.2, Vystorop I.V.1, Shevtsova E.F.2
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Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Issue: Vol 162, No 2 (2016)
- Pages: 228-230
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238063
- DOI: https://doi.org/10.1007/s10517-016-3582-0
- ID: 238063
Cite item
Abstract
Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.
About the authors
M. E. Neganova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
D. V. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
T. P. Serkova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
I. V. Vystorop
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
E. F. Shevtsova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka