Biological Activity of Spirocyclic Hydroxamic Acids
- Авторы: Neganova M.1, Mishchenko D.1, Serkova T.2, Vystorop I.1, Shevtsova E.2
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Учреждения:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Выпуск: Том 162, № 2 (2016)
- Страницы: 228-230
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238063
- DOI: https://doi.org/10.1007/s10517-016-3582-0
- ID: 238063
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Аннотация
Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.
Об авторах
M. Neganova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: neganova83@mail.ru
Россия, Chernogolovka
D. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka
T. Serkova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka
I. Vystorop
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka
E. Shevtsova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka
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