Individual Parameters of Cytokine Production in Healthy Siberian Caucasians
- 作者: Konenkov V.1, Shevchenko A.1, Prokof’ev V.1, Poveshchenko O.1, Lykov A.1
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隶属关系:
- Institute of Experimental and Clinical Lymphology
- 期: 卷 160, 编号 6 (2016)
- 页面: 795-797
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236950
- DOI: https://doi.org/10.1007/s10517-016-3312-7
- ID: 236950
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详细
The levels of spontaneous and concanavalin A-induced production of some key cytokines (TNF-α, IL-1β, IL-4, Il-6, and IL-10) were assessed in the cultures of mononuclear cells derived from healthy volunteers examined for polymorphism of the promotor sites of the respective genes. The presence of certain allelic variants in the promoter regions of human cytokine genes mostly determines the rates of induced and spontaneous cytokine production. Allelic variant -31C of IL-1β gene is associated with high production rate of the related cytokine. In addition, polymorphism of allelic variant C-590T of IL-4 gene significantly affects the production rates of IL-1β, TNF-α, IL-6, and IL-10.
作者简介
V. Konenkov
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
俄罗斯联邦, Novosibirsk
A. Shevchenko
Institute of Experimental and Clinical Lymphology
编辑信件的主要联系方式.
Email: shalla@mail.ru
俄罗斯联邦, Novosibirsk
V. Prokof’ev
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
俄罗斯联邦, Novosibirsk
O. Poveshchenko
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
俄罗斯联邦, Novosibirsk
A. Lykov
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
俄罗斯联邦, Novosibirsk
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