Individual Parameters of Cytokine Production in Healthy Siberian Caucasians
- Авторлар: Konenkov V.1, Shevchenko A.1, Prokof’ev V.1, Poveshchenko O.1, Lykov A.1
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Мекемелер:
- Institute of Experimental and Clinical Lymphology
- Шығарылым: Том 160, № 6 (2016)
- Беттер: 795-797
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236950
- DOI: https://doi.org/10.1007/s10517-016-3312-7
- ID: 236950
Дәйексөз келтіру
Аннотация
The levels of spontaneous and concanavalin A-induced production of some key cytokines (TNF-α, IL-1β, IL-4, Il-6, and IL-10) were assessed in the cultures of mononuclear cells derived from healthy volunteers examined for polymorphism of the promotor sites of the respective genes. The presence of certain allelic variants in the promoter regions of human cytokine genes mostly determines the rates of induced and spontaneous cytokine production. Allelic variant -31C of IL-1β gene is associated with high production rate of the related cytokine. In addition, polymorphism of allelic variant C-590T of IL-4 gene significantly affects the production rates of IL-1β, TNF-α, IL-6, and IL-10.
Авторлар туралы
V. Konenkov
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Ресей, Novosibirsk
A. Shevchenko
Institute of Experimental and Clinical Lymphology
Хат алмасуға жауапты Автор.
Email: shalla@mail.ru
Ресей, Novosibirsk
V. Prokof’ev
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Ресей, Novosibirsk
O. Poveshchenko
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Ресей, Novosibirsk
A. Lykov
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Ресей, Novosibirsk
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