Individual Parameters of Cytokine Production in Healthy Siberian Caucasians
- Authors: Konenkov V.I.1, Shevchenko A.V.1, Prokof’ev V.F.1, Poveshchenko O.V.1, Lykov A.P.1
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Affiliations:
- Institute of Experimental and Clinical Lymphology
- Issue: Vol 160, No 6 (2016)
- Pages: 795-797
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236950
- DOI: https://doi.org/10.1007/s10517-016-3312-7
- ID: 236950
Cite item
Abstract
The levels of spontaneous and concanavalin A-induced production of some key cytokines (TNF-α, IL-1β, IL-4, Il-6, and IL-10) were assessed in the cultures of mononuclear cells derived from healthy volunteers examined for polymorphism of the promotor sites of the respective genes. The presence of certain allelic variants in the promoter regions of human cytokine genes mostly determines the rates of induced and spontaneous cytokine production. Allelic variant -31C of IL-1β gene is associated with high production rate of the related cytokine. In addition, polymorphism of allelic variant C-590T of IL-4 gene significantly affects the production rates of IL-1β, TNF-α, IL-6, and IL-10.
About the authors
V. I. Konenkov
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Russian Federation, Novosibirsk
A. V. Shevchenko
Institute of Experimental and Clinical Lymphology
Author for correspondence.
Email: shalla@mail.ru
Russian Federation, Novosibirsk
V. F. Prokof’ev
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Russian Federation, Novosibirsk
O. V. Poveshchenko
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Russian Federation, Novosibirsk
A. P. Lykov
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Russian Federation, Novosibirsk