Individual Parameters of Cytokine Production in Healthy Siberian Caucasians
- Autores: Konenkov V.1, Shevchenko A.1, Prokof’ev V.1, Poveshchenko O.1, Lykov A.1
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Afiliações:
- Institute of Experimental and Clinical Lymphology
- Edição: Volume 160, Nº 6 (2016)
- Páginas: 795-797
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236950
- DOI: https://doi.org/10.1007/s10517-016-3312-7
- ID: 236950
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Resumo
The levels of spontaneous and concanavalin A-induced production of some key cytokines (TNF-α, IL-1β, IL-4, Il-6, and IL-10) were assessed in the cultures of mononuclear cells derived from healthy volunteers examined for polymorphism of the promotor sites of the respective genes. The presence of certain allelic variants in the promoter regions of human cytokine genes mostly determines the rates of induced and spontaneous cytokine production. Allelic variant -31C of IL-1β gene is associated with high production rate of the related cytokine. In addition, polymorphism of allelic variant C-590T of IL-4 gene significantly affects the production rates of IL-1β, TNF-α, IL-6, and IL-10.
Sobre autores
V. Konenkov
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Rússia, Novosibirsk
A. Shevchenko
Institute of Experimental and Clinical Lymphology
Autor responsável pela correspondência
Email: shalla@mail.ru
Rússia, Novosibirsk
V. Prokof’ev
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Rússia, Novosibirsk
O. Poveshchenko
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Rússia, Novosibirsk
A. Lykov
Institute of Experimental and Clinical Lymphology
Email: shalla@mail.ru
Rússia, Novosibirsk
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