Responses of Blood System to Doxorubicin/Docetaxel Chemotherapy in Patients with Breast Cancer
- Авторы: Goldberg V.1, Polyakova T.2,3, Popova N.1, Vysotskaya V.1, Simolina E.1, Dudnikova E.1, Goncharova N.1, Belevich Y.1, Grigor’ev E.1, Goldberg A.1, Dygai A.2
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Учреждения:
- Research Institute of Oncology
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of Russian Federation
- Выпуск: Том 168, № 2 (2019)
- Страницы: 275-279
- Раздел: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/242403
- DOI: https://doi.org/10.1007/s10517-019-04690-y
- ID: 242403
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Аннотация
We studied the effects of combined chemotherapy with doxorubicin/docetaxel on erythroid and granulocytic hematopoietic lineages with particular attention focused on their recovery in patients with stages III-IV breast cancer. Intensification of differentiation of erythroid and granulocytic CFU (even under conditions of their suppressed proliferation) provided the increase in the content of mature and morphologically differentiated elements in the bone marrow and peripheral blood. High proliferative activity of erythroid and granulomonocytic precursors resulted from enhanced production of hematopoiesis-stimulating activities by microenvironment elements.
Об авторах
V. Goldberg
Research Institute of Oncology
Автор, ответственный за переписку.
Email: goldbergve@mail.ru
Россия, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of Russian Federation
Email: goldbergve@mail.ru
Россия, Tomsk; Tomsk
N. Popova
Research Institute of Oncology
Email: goldbergve@mail.ru
Россия, Tomsk
V. Vysotskaya
Research Institute of Oncology
Email: goldbergve@mail.ru
Россия, Tomsk
E. Simolina
Research Institute of Oncology
Email: goldbergve@mail.ru
Россия, Tomsk
E. Dudnikova
Research Institute of Oncology
Email: goldbergve@mail.ru
Россия, Tomsk
N. Goncharova
Research Institute of Oncology
Email: goldbergve@mail.ru
Россия, Tomsk
Yu. Belevich
Research Institute of Oncology
Email: goldbergve@mail.ru
Россия, Tomsk
E. Grigor’ev
Research Institute of Oncology
Email: goldbergve@mail.ru
Россия, Tomsk
A. Goldberg
Research Institute of Oncology
Email: goldbergve@mail.ru
Россия, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: goldbergve@mail.ru
Россия, Tomsk
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