Responses of Blood System to Doxorubicin/Docetaxel Chemotherapy in Patients with Breast Cancer
- Autores: Goldberg V.1, Polyakova T.2,3, Popova N.1, Vysotskaya V.1, Simolina E.1, Dudnikova E.1, Goncharova N.1, Belevich Y.1, Grigor’ev E.1, Goldberg A.1, Dygai A.2
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Afiliações:
- Research Institute of Oncology
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of Russian Federation
- Edição: Volume 168, Nº 2 (2019)
- Páginas: 275-279
- Seção: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/242403
- DOI: https://doi.org/10.1007/s10517-019-04690-y
- ID: 242403
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Resumo
We studied the effects of combined chemotherapy with doxorubicin/docetaxel on erythroid and granulocytic hematopoietic lineages with particular attention focused on their recovery in patients with stages III-IV breast cancer. Intensification of differentiation of erythroid and granulocytic CFU (even under conditions of their suppressed proliferation) provided the increase in the content of mature and morphologically differentiated elements in the bone marrow and peripheral blood. High proliferative activity of erythroid and granulomonocytic precursors resulted from enhanced production of hematopoiesis-stimulating activities by microenvironment elements.
Sobre autores
V. Goldberg
Research Institute of Oncology
Autor responsável pela correspondência
Email: goldbergve@mail.ru
Rússia, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of Russian Federation
Email: goldbergve@mail.ru
Rússia, Tomsk; Tomsk
N. Popova
Research Institute of Oncology
Email: goldbergve@mail.ru
Rússia, Tomsk
V. Vysotskaya
Research Institute of Oncology
Email: goldbergve@mail.ru
Rússia, Tomsk
E. Simolina
Research Institute of Oncology
Email: goldbergve@mail.ru
Rússia, Tomsk
E. Dudnikova
Research Institute of Oncology
Email: goldbergve@mail.ru
Rússia, Tomsk
N. Goncharova
Research Institute of Oncology
Email: goldbergve@mail.ru
Rússia, Tomsk
Yu. Belevich
Research Institute of Oncology
Email: goldbergve@mail.ru
Rússia, Tomsk
E. Grigor’ev
Research Institute of Oncology
Email: goldbergve@mail.ru
Rússia, Tomsk
A. Goldberg
Research Institute of Oncology
Email: goldbergve@mail.ru
Rússia, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: goldbergve@mail.ru
Rússia, Tomsk
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