Email this article Responses of Blood System to Doxorubicin/Docetaxel Chemotherapy in Patients with Breast Cancer
- Authors: Goldberg V.E.1, Polyakova T.Y.2,3, Popova N.O.1, Vysotskaya V.V.1, Simolina E.I.1, Dudnikova E.A.1, Goncharova N.M.1, Belevich Y.V.1, Grigor’ev E.G.1, Goldberg A.V.1, Dygai A.M.2
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Affiliations:
- Research Institute of Oncology
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of Russian Federation
- Issue: Vol 168, No 2 (2019)
- Pages: 275-279
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/242403
- DOI: https://doi.org/10.1007/s10517-019-04690-y
- ID: 242403
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Abstract
We studied the effects of combined chemotherapy with doxorubicin/docetaxel on erythroid and granulocytic hematopoietic lineages with particular attention focused on their recovery in patients with stages III-IV breast cancer. Intensification of differentiation of erythroid and granulocytic CFU (even under conditions of their suppressed proliferation) provided the increase in the content of mature and morphologically differentiated elements in the bone marrow and peripheral blood. High proliferative activity of erythroid and granulomonocytic precursors resulted from enhanced production of hematopoiesis-stimulating activities by microenvironment elements.
About the authors
V. E. Goldberg
Research Institute of Oncology
Author for correspondence.
Email: goldbergve@mail.ru
Russian Federation, Tomsk
T. Yu. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of Russian Federation
Email: goldbergve@mail.ru
Russian Federation, Tomsk; Tomsk
N. O. Popova
Research Institute of Oncology
Email: goldbergve@mail.ru
Russian Federation, Tomsk
V. V. Vysotskaya
Research Institute of Oncology
Email: goldbergve@mail.ru
Russian Federation, Tomsk
E. I. Simolina
Research Institute of Oncology
Email: goldbergve@mail.ru
Russian Federation, Tomsk
E. A. Dudnikova
Research Institute of Oncology
Email: goldbergve@mail.ru
Russian Federation, Tomsk
N. M. Goncharova
Research Institute of Oncology
Email: goldbergve@mail.ru
Russian Federation, Tomsk
Yu. V. Belevich
Research Institute of Oncology
Email: goldbergve@mail.ru
Russian Federation, Tomsk
E. G. Grigor’ev
Research Institute of Oncology
Email: goldbergve@mail.ru
Russian Federation, Tomsk
A. V. Goldberg
Research Institute of Oncology
Email: goldbergve@mail.ru
Russian Federation, Tomsk
A. M. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: goldbergve@mail.ru
Russian Federation, Tomsk
