Effect of Antiobiotic-Induced Disbiosis and Its Correction with Probiotics on Myocardial Tolerance to Ischemia-Reperfusion Injury in SPF Rats
- Авторы: Borshchev Y.1, Sinitsa A.1, Zakharchenko M.1, Borshchev V.1, Burovenko I.1, Galagudza M.1
-
Учреждения:
- Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
- Выпуск: Том 166, № 4 (2019)
- Страницы: 440-443
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241089
- DOI: https://doi.org/10.1007/s10517-019-04368-5
- ID: 241089
Цитировать
Аннотация
Changes in morphofunctional parameters of the isolated heart subjected to global ischemia-reperfusion were studied in SPF Wistar rats with antibiotic-induced dysbiosis (AID) treated with lyophilized yeast Saccharomyces boulardii and inactivated probiotic bacteria Lactobacillus reuteri KR2017. In contrast to S. boulardii, correction of dysbiosis with L. reuteri KR2017 against the background of gastric hypersecretion and standard antimicrobial therapy led to an increase in fat content and a decrease in free and bound water in tissues and to a significant reduction in myocardial infarct size caused by ischemia/ reperfusion injury.
Об авторах
Yu. Borshchev
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Россия, St. Petersburg
A. Sinitsa
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Россия, St. Petersburg
M. Zakharchenko
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Россия, St. Petersburg
V. Borshchev
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Россия, St. Petersburg
I. Burovenko
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Россия, St. Petersburg
M. Galagudza
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: galagudza@almazovcentre.ru
Россия, St. Petersburg
![](/img/style/loading.gif)