Effect of Antiobiotic-Induced Disbiosis and Its Correction with Probiotics on Myocardial Tolerance to Ischemia-Reperfusion Injury in SPF Rats
- Authors: Borshchev Y.Y.1, Sinitsa A.V.1, Zakharchenko M.M.1, Borshchev V.Y.1, Burovenko I.Y.1, Galagudza M.M.1
-
Affiliations:
- Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
- Issue: Vol 166, No 4 (2019)
- Pages: 440-443
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241089
- DOI: https://doi.org/10.1007/s10517-019-04368-5
- ID: 241089
Cite item
Abstract
Changes in morphofunctional parameters of the isolated heart subjected to global ischemia-reperfusion were studied in SPF Wistar rats with antibiotic-induced dysbiosis (AID) treated with lyophilized yeast Saccharomyces boulardii and inactivated probiotic bacteria Lactobacillus reuteri KR2017. In contrast to S. boulardii, correction of dysbiosis with L. reuteri KR2017 against the background of gastric hypersecretion and standard antimicrobial therapy led to an increase in fat content and a decrease in free and bound water in tissues and to a significant reduction in myocardial infarct size caused by ischemia/ reperfusion injury.
About the authors
Yu. Yu. Borshchev
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Russian Federation, St. Petersburg
A. V. Sinitsa
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Russian Federation, St. Petersburg
M. M. Zakharchenko
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Russian Federation, St. Petersburg
V. Yu. Borshchev
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Russian Federation, St. Petersburg
I. Yu. Burovenko
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Russian Federation, St. Petersburg
M. M. Galagudza
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Author for correspondence.
Email: galagudza@almazovcentre.ru
Russian Federation, St. Petersburg