Effect of Antiobiotic-Induced Disbiosis and Its Correction with Probiotics on Myocardial Tolerance to Ischemia-Reperfusion Injury in SPF Rats
- Авторлар: Borshchev Y.1, Sinitsa A.1, Zakharchenko M.1, Borshchev V.1, Burovenko I.1, Galagudza M.1
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Мекемелер:
- Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
- Шығарылым: Том 166, № 4 (2019)
- Беттер: 440-443
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241089
- DOI: https://doi.org/10.1007/s10517-019-04368-5
- ID: 241089
Дәйексөз келтіру
Аннотация
Changes in morphofunctional parameters of the isolated heart subjected to global ischemia-reperfusion were studied in SPF Wistar rats with antibiotic-induced dysbiosis (AID) treated with lyophilized yeast Saccharomyces boulardii and inactivated probiotic bacteria Lactobacillus reuteri KR2017. In contrast to S. boulardii, correction of dysbiosis with L. reuteri KR2017 against the background of gastric hypersecretion and standard antimicrobial therapy led to an increase in fat content and a decrease in free and bound water in tissues and to a significant reduction in myocardial infarct size caused by ischemia/ reperfusion injury.
Авторлар туралы
Yu. Borshchev
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Ресей, St. Petersburg
A. Sinitsa
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Ресей, St. Petersburg
M. Zakharchenko
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Ресей, St. Petersburg
V. Borshchev
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Ресей, St. Petersburg
I. Burovenko
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: galagudza@almazovcentre.ru
Ресей, St. Petersburg
M. Galagudza
Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: galagudza@almazovcentre.ru
Ресей, St. Petersburg
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