Complex Analysis of Diffusion Transport and Microstructure of an Intervertebral Disk
- Авторы: Byvaltsev V.1,2,3,4, Kolesnikov S.5,6, Belykh E.1,2, Stepanov I.1,2, Kalinin A.1,2, Bardonova L.1,2, Sudakov N.1,7, Klimenkov I.7, Nikiforov S.1, Semenov A.8, Perfil’ev D.8, Bespyatykh I.4, Antipina S.4, Giers M.1, Prul M.1
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Учреждения:
- Irkutsk Research Center of Surgery and Traumatology
- Irkutsk State Medical University
- Irkutsk State Medical Academy of Postgraduate Education
- Railway Clinical Hospital at Irkutsk Passengers Station
- Research Center of Problems of Family Health and Human Reproduction
- M. V. Lomonosov Moscow State University
- Limnological Institute, Siberian Division of the Russian Academy of Sciences
- Irkutsk Regional Forensic Medical Expert Bureau
- Выпуск: Том 164, № 2 (2017)
- Страницы: 223-228
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239522
- DOI: https://doi.org/10.1007/s10517-017-3963-z
- ID: 239522
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Аннотация
We studied the relationship between diffusion transport and morphological and microstructural organization of extracellular matrix of human intervertebral disk. Specimens of the lumbar intervertebral disks without abnormalities were studied ex vivo by diffusion-weighed magnetic resonance imaging, histological and immunohistochemical methods, and electron microscopy. Distribution of the diffusion coefficient in various compartments of the intervertebral disk was studied. Significant correlations between diffusion coefficient and cell density in the nucleus pulposus, posterior aspects of annulus fibrosus, and endplate at the level of the posterior annulus fibrosus were detected for each disk. In disks with nucleus pulposus diffusion coefficient below 15×10-4 mm2/sec, collagens X and XI were detected apart from aggrecan and collagens I and II. The results supplement the concept on the relationship between the microstructure and cell composition of various compartments of the intervertebral disk and parameters of nutrient transport.
Об авторах
V. Byvaltsev
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University; Irkutsk State Medical Academy of Postgraduate Education; Railway Clinical Hospital at Irkutsk Passengers Station
Автор, ответственный за переписку.
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Irkutsk; Irkutsk; Irkutsk
S. Kolesnikov
Research Center of Problems of Family Health and Human Reproduction; M. V. Lomonosov Moscow State University
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Moscow
E. Belykh
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Irkutsk
I. Stepanov
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Irkutsk
A. Kalinin
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Irkutsk
L. Bardonova
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Irkutsk
N. Sudakov
Irkutsk Research Center of Surgery and Traumatology; Limnological Institute, Siberian Division of the Russian Academy of Sciences
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Irkutsk
I. Klimenkov
Limnological Institute, Siberian Division of the Russian Academy of Sciences
Email: byval75vadim@yandex.ru
Россия, Irkutsk
S. Nikiforov
Irkutsk Research Center of Surgery and Traumatology
Email: byval75vadim@yandex.ru
Россия, Irkutsk
A. Semenov
Irkutsk Regional Forensic Medical Expert Bureau
Email: byval75vadim@yandex.ru
Россия, Irkutsk
D. Perfil’ev
Irkutsk Regional Forensic Medical Expert Bureau
Email: byval75vadim@yandex.ru
Россия, Irkutsk
I. Bespyatykh
Railway Clinical Hospital at Irkutsk Passengers Station
Email: byval75vadim@yandex.ru
Россия, Irkutsk
S. Antipina
Railway Clinical Hospital at Irkutsk Passengers Station
Email: byval75vadim@yandex.ru
Россия, Irkutsk
M. Giers
Irkutsk Research Center of Surgery and Traumatology
Email: byval75vadim@yandex.ru
Россия, Irkutsk
M. Prul
Irkutsk Research Center of Surgery and Traumatology
Email: byval75vadim@yandex.ru
Россия, Irkutsk