Complex Analysis of Diffusion Transport and Microstructure of an Intervertebral Disk
- Авторлар: Byvaltsev V.1,2,3,4, Kolesnikov S.5,6, Belykh E.1,2, Stepanov I.1,2, Kalinin A.1,2, Bardonova L.1,2, Sudakov N.1,7, Klimenkov I.7, Nikiforov S.1, Semenov A.8, Perfil’ev D.8, Bespyatykh I.4, Antipina S.4, Giers M.1, Prul M.1
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Мекемелер:
- Irkutsk Research Center of Surgery and Traumatology
- Irkutsk State Medical University
- Irkutsk State Medical Academy of Postgraduate Education
- Railway Clinical Hospital at Irkutsk Passengers Station
- Research Center of Problems of Family Health and Human Reproduction
- M. V. Lomonosov Moscow State University
- Limnological Institute, Siberian Division of the Russian Academy of Sciences
- Irkutsk Regional Forensic Medical Expert Bureau
- Шығарылым: Том 164, № 2 (2017)
- Беттер: 223-228
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239522
- DOI: https://doi.org/10.1007/s10517-017-3963-z
- ID: 239522
Дәйексөз келтіру
Аннотация
We studied the relationship between diffusion transport and morphological and microstructural organization of extracellular matrix of human intervertebral disk. Specimens of the lumbar intervertebral disks without abnormalities were studied ex vivo by diffusion-weighed magnetic resonance imaging, histological and immunohistochemical methods, and electron microscopy. Distribution of the diffusion coefficient in various compartments of the intervertebral disk was studied. Significant correlations between diffusion coefficient and cell density in the nucleus pulposus, posterior aspects of annulus fibrosus, and endplate at the level of the posterior annulus fibrosus were detected for each disk. In disks with nucleus pulposus diffusion coefficient below 15×10-4 mm2/sec, collagens X and XI were detected apart from aggrecan and collagens I and II. The results supplement the concept on the relationship between the microstructure and cell composition of various compartments of the intervertebral disk and parameters of nutrient transport.
Авторлар туралы
V. Byvaltsev
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University; Irkutsk State Medical Academy of Postgraduate Education; Railway Clinical Hospital at Irkutsk Passengers Station
Хат алмасуға жауапты Автор.
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Irkutsk; Irkutsk; Irkutsk
S. Kolesnikov
Research Center of Problems of Family Health and Human Reproduction; M. V. Lomonosov Moscow State University
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Moscow
E. Belykh
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Irkutsk
I. Stepanov
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Irkutsk
A. Kalinin
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Irkutsk
L. Bardonova
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Irkutsk
N. Sudakov
Irkutsk Research Center of Surgery and Traumatology; Limnological Institute, Siberian Division of the Russian Academy of Sciences
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Irkutsk
I. Klimenkov
Limnological Institute, Siberian Division of the Russian Academy of Sciences
Email: byval75vadim@yandex.ru
Ресей, Irkutsk
S. Nikiforov
Irkutsk Research Center of Surgery and Traumatology
Email: byval75vadim@yandex.ru
Ресей, Irkutsk
A. Semenov
Irkutsk Regional Forensic Medical Expert Bureau
Email: byval75vadim@yandex.ru
Ресей, Irkutsk
D. Perfil’ev
Irkutsk Regional Forensic Medical Expert Bureau
Email: byval75vadim@yandex.ru
Ресей, Irkutsk
I. Bespyatykh
Railway Clinical Hospital at Irkutsk Passengers Station
Email: byval75vadim@yandex.ru
Ресей, Irkutsk
S. Antipina
Railway Clinical Hospital at Irkutsk Passengers Station
Email: byval75vadim@yandex.ru
Ресей, Irkutsk
M. Giers
Irkutsk Research Center of Surgery and Traumatology
Email: byval75vadim@yandex.ru
Ресей, Irkutsk
M. Prul
Irkutsk Research Center of Surgery and Traumatology
Email: byval75vadim@yandex.ru
Ресей, Irkutsk