Enviar artigo por via de e-mail Complex Analysis of Diffusion Transport and Microstructure of an Intervertebral Disk
- Autores: Byvaltsev V.1,2,3,4, Kolesnikov S.5,6, Belykh E.1,2, Stepanov I.1,2, Kalinin A.1,2, Bardonova L.1,2, Sudakov N.1,7, Klimenkov I.7, Nikiforov S.1, Semenov A.8, Perfil’ev D.8, Bespyatykh I.4, Antipina S.4, Giers M.1, Prul M.1
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Afiliações:
- Irkutsk Research Center of Surgery and Traumatology
- Irkutsk State Medical University
- Irkutsk State Medical Academy of Postgraduate Education
- Railway Clinical Hospital at Irkutsk Passengers Station
- Research Center of Problems of Family Health and Human Reproduction
- M. V. Lomonosov Moscow State University
- Limnological Institute, Siberian Division of the Russian Academy of Sciences
- Irkutsk Regional Forensic Medical Expert Bureau
- Edição: Volume 164, Nº 2 (2017)
- Páginas: 223-228
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239522
- DOI: https://doi.org/10.1007/s10517-017-3963-z
- ID: 239522
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Resumo
We studied the relationship between diffusion transport and morphological and microstructural organization of extracellular matrix of human intervertebral disk. Specimens of the lumbar intervertebral disks without abnormalities were studied ex vivo by diffusion-weighed magnetic resonance imaging, histological and immunohistochemical methods, and electron microscopy. Distribution of the diffusion coefficient in various compartments of the intervertebral disk was studied. Significant correlations between diffusion coefficient and cell density in the nucleus pulposus, posterior aspects of annulus fibrosus, and endplate at the level of the posterior annulus fibrosus were detected for each disk. In disks with nucleus pulposus diffusion coefficient below 15×10-4 mm2/sec, collagens X and XI were detected apart from aggrecan and collagens I and II. The results supplement the concept on the relationship between the microstructure and cell composition of various compartments of the intervertebral disk and parameters of nutrient transport.
Sobre autores
V. Byvaltsev
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University; Irkutsk State Medical Academy of Postgraduate Education; Railway Clinical Hospital at Irkutsk Passengers Station
Autor responsável pela correspondência
Email: byval75vadim@yandex.ru
Rússia, Irkutsk; Irkutsk; Irkutsk; Irkutsk
S. Kolesnikov
Research Center of Problems of Family Health and Human Reproduction; M. V. Lomonosov Moscow State University
Email: byval75vadim@yandex.ru
Rússia, Irkutsk; Moscow
E. Belykh
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Rússia, Irkutsk; Irkutsk
I. Stepanov
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Rússia, Irkutsk; Irkutsk
A. Kalinin
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Rússia, Irkutsk; Irkutsk
L. Bardonova
Irkutsk Research Center of Surgery and Traumatology; Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Rússia, Irkutsk; Irkutsk
N. Sudakov
Irkutsk Research Center of Surgery and Traumatology; Limnological Institute, Siberian Division of the Russian Academy of Sciences
Email: byval75vadim@yandex.ru
Rússia, Irkutsk; Irkutsk
I. Klimenkov
Limnological Institute, Siberian Division of the Russian Academy of Sciences
Email: byval75vadim@yandex.ru
Rússia, Irkutsk
S. Nikiforov
Irkutsk Research Center of Surgery and Traumatology
Email: byval75vadim@yandex.ru
Rússia, Irkutsk
A. Semenov
Irkutsk Regional Forensic Medical Expert Bureau
Email: byval75vadim@yandex.ru
Rússia, Irkutsk
D. Perfil’ev
Irkutsk Regional Forensic Medical Expert Bureau
Email: byval75vadim@yandex.ru
Rússia, Irkutsk
I. Bespyatykh
Railway Clinical Hospital at Irkutsk Passengers Station
Email: byval75vadim@yandex.ru
Rússia, Irkutsk
S. Antipina
Railway Clinical Hospital at Irkutsk Passengers Station
Email: byval75vadim@yandex.ru
Rússia, Irkutsk
M. Giers
Irkutsk Research Center of Surgery and Traumatology
Email: byval75vadim@yandex.ru
Rússia, Irkutsk
M. Prul
Irkutsk Research Center of Surgery and Traumatology
Email: byval75vadim@yandex.ru
Rússia, Irkutsk
