Screening of Some Dioxaboreninopyridine and Aniline Derivatives for Carcinogenic Properties Using a Model Cell-Free System of Regenerating Rat Liver
- Авторы: Terent’ev A.1, Syatkin S.2, Kirichuk A.2, Soldatenkov A.2, Kutyakov S.2, Neborak E.2, Shevkun N.2, Kuznetsova O.2, Skorik A.2
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Учреждения:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Peoples’ Friendship University of Russia
- Выпуск: Том 162, № 6 (2017)
- Страницы: 801-807
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238585
- DOI: https://doi.org/10.1007/s10517-017-3717-y
- ID: 238585
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Аннотация
We studied the effects of some aniline and dioxaborininopyridine derivatives on the rate of oxidative deamination of putrescine and polyamines in a tissue with high mitotic index. These effects were evaluated quantitatively by measuring diamine oxidase and polyamine oxidase activities in a model cell-free test system of regenerating rat liver tissue. Aniline derivatives exhibited mainly antiproliferative effects and promoted oxidative degradation of putrescine, spermidine, and spermine. Dioxaborininopyridine derivatives inhibited this process, thus exhibiting carcinogenic properties.
Об авторах
A. Terent’ev
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: syata@mail.ru
Россия, Moscow
S. Syatkin
Peoples’ Friendship University of Russia
Автор, ответственный за переписку.
Email: syata@mail.ru
Россия, Moscow
A. Kirichuk
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Россия, Moscow
A. Soldatenkov
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Россия, Moscow
S. Kutyakov
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Россия, Moscow
E. Neborak
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Россия, Moscow
N. Shevkun
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Россия, Moscow
O. Kuznetsova
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Россия, Moscow
A. Skorik
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Россия, Moscow
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