Screening of Some Dioxaboreninopyridine and Aniline Derivatives for Carcinogenic Properties Using a Model Cell-Free System of Regenerating Rat Liver
- Авторлар: Terent’ev A.1, Syatkin S.2, Kirichuk A.2, Soldatenkov A.2, Kutyakov S.2, Neborak E.2, Shevkun N.2, Kuznetsova O.2, Skorik A.2
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Мекемелер:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Peoples’ Friendship University of Russia
- Шығарылым: Том 162, № 6 (2017)
- Беттер: 801-807
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238585
- DOI: https://doi.org/10.1007/s10517-017-3717-y
- ID: 238585
Дәйексөз келтіру
Аннотация
We studied the effects of some aniline and dioxaborininopyridine derivatives on the rate of oxidative deamination of putrescine and polyamines in a tissue with high mitotic index. These effects were evaluated quantitatively by measuring diamine oxidase and polyamine oxidase activities in a model cell-free test system of regenerating rat liver tissue. Aniline derivatives exhibited mainly antiproliferative effects and promoted oxidative degradation of putrescine, spermidine, and spermine. Dioxaborininopyridine derivatives inhibited this process, thus exhibiting carcinogenic properties.
Авторлар туралы
A. Terent’ev
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: syata@mail.ru
Ресей, Moscow
S. Syatkin
Peoples’ Friendship University of Russia
Хат алмасуға жауапты Автор.
Email: syata@mail.ru
Ресей, Moscow
A. Kirichuk
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Ресей, Moscow
A. Soldatenkov
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Ресей, Moscow
S. Kutyakov
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Ресей, Moscow
E. Neborak
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Ресей, Moscow
N. Shevkun
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Ресей, Moscow
O. Kuznetsova
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Ресей, Moscow
A. Skorik
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Ресей, Moscow