Screening of Some Dioxaboreninopyridine and Aniline Derivatives for Carcinogenic Properties Using a Model Cell-Free System of Regenerating Rat Liver
- Autores: Terent’ev A.1, Syatkin S.2, Kirichuk A.2, Soldatenkov A.2, Kutyakov S.2, Neborak E.2, Shevkun N.2, Kuznetsova O.2, Skorik A.2
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Afiliações:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Peoples’ Friendship University of Russia
- Edição: Volume 162, Nº 6 (2017)
- Páginas: 801-807
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238585
- DOI: https://doi.org/10.1007/s10517-017-3717-y
- ID: 238585
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Resumo
We studied the effects of some aniline and dioxaborininopyridine derivatives on the rate of oxidative deamination of putrescine and polyamines in a tissue with high mitotic index. These effects were evaluated quantitatively by measuring diamine oxidase and polyamine oxidase activities in a model cell-free test system of regenerating rat liver tissue. Aniline derivatives exhibited mainly antiproliferative effects and promoted oxidative degradation of putrescine, spermidine, and spermine. Dioxaborininopyridine derivatives inhibited this process, thus exhibiting carcinogenic properties.
Sobre autores
A. Terent’ev
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: syata@mail.ru
Rússia, Moscow
S. Syatkin
Peoples’ Friendship University of Russia
Autor responsável pela correspondência
Email: syata@mail.ru
Rússia, Moscow
A. Kirichuk
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Rússia, Moscow
A. Soldatenkov
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Rússia, Moscow
S. Kutyakov
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Rússia, Moscow
E. Neborak
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Rússia, Moscow
N. Shevkun
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Rússia, Moscow
O. Kuznetsova
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Rússia, Moscow
A. Skorik
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Rússia, Moscow
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